… This subtype presents a 10 to 100-fold higher affinity for the … subtypes of a hybrid compound
class containing Prazosin and … of alpha 1adrenoceptor subtype mRNAs in human prostate: …

… the adrenergic pathways for alpha 1 and alpha 2 receptors … Subtypes show similar binding
affinities but have different … hypertension, benign prostatic hyperplasia (prazosin, doxazosin, …

… binding studies using [ 3 H]prazosin/[ 125 I]HEAT and [ 3 H]L-771.688 in human and animal
… the tissue to NE. The estimation of affinity (p A2 -value) at alpha 1 -adrenoceptors mediating …

… TUR specimen of a patient with benign prostatic hyperplasia … Prazosin was the first selective
α 1 -adrenoceptor antagonist … DHT has a stronger affinity to the nuclear bound androgen …

… Alpha 1 -adrenergic receptors have also been shown to … , doxazosin, prazosin and terazosin
block the three α 1 -AR subtypes, … that even noradrenaline has a high affinity for α 1 -AR, this …

… to voiding dysfunction in benign prostatic hyperplasia. α 1 -… of 3 H-prazosin binding across
different LUT tissues from rats … , characterized by a lower affinity for prazosin (White et al. 2019)…

… minimal subtype selectivity, such as prazosin and tamsulosin, to treat hypertension and benign
prostatic hyperplasia… Prazosin affinity for the α 1B -AR mutants, however, was unchanged …

… Prazosin suffers from requiring multiple daily doses, whereas terazosin and … alpha-1 blocker
with a high degree of adrenoceptor subtype selectivity. Silodosin has a high affinity for alpha-…

… stromal tissue, especially in the periurethral zone of the prostate, … rather than the α1-AR
subtype affinity as previously reported. … , their affinity for prostatic and renal α1-adrenoceptors in …

… [3H]prazosin/[125I]HEAT and [3H]L-771.688 in human and animal tissues that are known to
have … α1D-antagonist with a binding affinity for α1D threefold higher than that of α1A receptor …